Effects of norepinephrine on regional blood flow and oxygen extraction capabilities during endotoxic shock

摘要

ew explored the effects of norepinephrine on blood flow distribution and oxygen extraction capabil- ities during hyperdynamic endotoxic shock. Twelve anesthetized and mechanically ventilated dogs received 2 mg/kg of Esherichia coli endotoxin followed by a general saline infusion and were then randomly divided into two groups: six received norepinephrine (1 μg/kg/min), and isx served as con- trol subjects. The prepinephrine group maintained higher mean arterial pressure, cardiac index, left ventricular stroke work index and hepatic arterial blood flow without altering blood flow to portal, mesenteric, and renal beds.