Antimicrobial and Antifouling Hydrogels Formed In Situ from Polycarbonate and Poly(ethylene glycol) via Michael Addition

摘要

The rapid emergence and spread of antibiotic-resistant microbes have made the treatment of microbial infections complicated.'1'2' It is estimated that 50% of the hospitalized patients suffer from nosocomial infection with drug-resistant bacteria annually in the United States, where Methicillin-resistant S. aureus (MRSA, Gram-positive) is a major cause of the infection acquired in both intensive care units and biomaterials related implants.[3] This has contributed not only to increased morbidity and mortality, but also a multibillion dollar burden to the health care system because of prolonged hospital stay and increased medical cost.[4]