Porphyrinic Metal-Organic Frameworks Coated Cold Nanorods as a Versatile Nanoplatform for Combined Photodynamic/Photothermal/Chemotherapy of Tumor

摘要

In this paper, a simple, but effective method is reported to construct the core-shell gold nanorod@metal-organic frameworks (AuNR@MOFs) as a multifunctional theranostic platform by using functionalized AuNRs as seed crystal for the growth of porphyrinic MOFs on the surface of AuNR. Such a delicate tunable core-shell composite not only possesses the improved drug loading efficiency, near-infrared light-trigger drug release, and fluorescence imaging, but also can produce reactive oxygen species as well as photothermal activity to achieve combined cancer therapy. It is further demonstrated that the camptothecin loaded AuNR@MOFs show distinctively synergistic efficiency for damaging the cancer cell in vitro and inhibiting the tumor growth and metastasis in vivo. The development of this high-performance incorporated nanostructure will provide more perspectives in the design of versatile nanomaterials for biomedical applications.