Atrophy and apoptosis in ventral prostate of rats induced by 5α -reductase inhibitor, epristeride

摘要

Apoptosis occurred in both castra- tion-and epristeride-treatment group. Both the degree and extent of apoptosis are much larger in the group of castration than that of epristeride-treated group. Both epristeride and castration decreased the prostate wet weight and DNA content but increased the prostate DNA concentration. Maximal or near maximal decrease were seen by d 10 in both groups. Apoptosis induced By epristeride was one of mechanisms in the treatment of Benign prostatic phyerplasia and the activity of ACP could Be used as a marker of prostate atrophy.