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Do case‐only designs yield consistent results across design and different databases? A case study of hip fractures and benzodiazepines

机译：仅案例设计会在设计和不同数据库之间产生一致的结果吗？髋部骨折和苯二氮卓类药物的案例研究

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BackgroundThe case‐crossover (CXO) and self‐controlled case series (SCCS) designs are increasingly used in pharmacoepidemiology. In both, relative risk estimates are obtained within persons, implicitly controlling for time‐fixed confounding variables.

机译：背景病例交叉（CXO）和自控病例系列（SCCS）设计越来越多地用于药物流行病学。在这两种方法中，都可以在人员内部获得相对风险估计，从而隐含地控制了固定时间的混杂变量。

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期刊名称 Wiley-Blackwell Online Open
作者
Gema Requena; John Logie; Elisa Martin; Nada Boudiaf; Rocío González González; Consuelo Huerta; Arturo Alvarez; David Webb; Andrew Bate; Luis A. García Rodríguez; Robert Reynolds; Raymond Schlienger; Helga Gardarsdottir; Mark de Groot; Olaf H. Klungel; Fancisco de Abajo; Ian J. Douglas;
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年(卷),期 -1(25),Suppl Suppl 1
年度 -1
页码 79–87
总页数 9
原文格式 PDF
正文语种
中图分类
关键词
case crossover (CXO) self‐controlled case series (SCCS) benzodiazepines hip fractures electronic healthcare records databases (DBs) pharmacoepidemiology;

机译：病例交叉（CXO）;自控病例系列（SCCS）;苯二氮卓类药物;髋部骨折;电子医疗记录数据库（DBs）;药物流行病学;

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专利

1. Structure-Based Design of a Benzodiazepine Scaffold Yields a Potent Allosteric Inhibitor of Hepatitis C NS5B RNA Polymerase [J] . Vandyck K, Cummings MD, Nyanguile O, Journal of Medicinal Chemistry . 2009,第14期

机译：基于结构的苯二氮卓支架的设计产生丙型肝炎NS5B RNA聚合酶的强变构抑制剂。
2. Rationale and design of the HIP fracture Accelerated surgical TreaTment And Care tracK (HIP ATTACK) Trial: a protocol for an international randomised controlled trial evaluating early surgery for hip fracture patients [J] . Flavia K Borges, Mohit Bhandari, Ameen Patel, BMJ Open . 2019,第4期

机译：HIP骨折加速外科治疗和护理追踪（HIP ATTACK）试验的原理和设计：一项评估髋部骨折患者早期手术的国际随机对照试验的方案
3. Young age and wedge stem design are risk factors for periprosthetic fracture after arthroplasty due to hip fracture. A case-control study. [J] . Sarvilinna R, Huhtala H, Pajamaki J Acta orthopaedica. . 2005,第1期

机译：年轻人年龄和楔形茎设计是髋关节骨折置换术后假体周围骨折的危险因素。病例对照研究。
4. Complete Optimized Fracturing Design Methodology Yields Efficient Enhanced Production Performance in the South Sulige Field [C] . Liu S., Fan W., Falxa P. International Petroleum Technology Conference . 2013

机译：完整的优化压裂设计方法在南苏丽域内产生高效增强的生产性能
5. Part One. Synthesis of optically active tryptophan derivatives with potential activity as indoleamine 2,3-dioxygenase inhibitors: An approach via asymmetric catalytic hydrogenation. Part Two. Design, synthesis and pharmacology of selective ligands for alpha1-containing GABA(A)/benzodiazepine receptor subtypes: SAR studies of beta-carbolines at positions -3 and -6 and their corresponding bivalent ligands. Part Three. First enantiospecific total synthesis of the important biogenetic intermediates, (+)-polyneuridine and (+)-polyneuridine aldehyde, as well as 16-epi-vellosimine and macusine A. [D] . Yin, Wenyuan. 2007

机译：第一部分。具有吲哚胺2,3-二加氧酶抑制剂潜在活性的旋光色氨酸衍生物的合成：一种通过不对称催化氢化的方法。第二部分。含α1的GABA（A）/苯并二氮杂receptor受体亚型的选择性配体的设计，合成和药理作用：位于-3和-6位的β-咔啉及其相应的二价配体的SAR研究。第三部分。重要生物遗传中间体，（+）-聚神经氨酸和（+）-聚神经氨酸醛，以及16-表-维西辛和Macusine A的首次对映体全合成。
6. Examining Differences in Recovery Outcomes between Male and Female Hip Fracture Patients: Design and Baseline Results of a Prospective Cohort Study from the Baltimore Hip Studies [O] . Denise Orwig, Marc C. Hochberg, Ann L. Gruber-Baldini, -1

机译：检查男性和女性髋部骨折患者的恢复结果差异：来自巴尔的摩髋关节研究的前瞻性队列研究的设计和基线结果
7. Hip/femur fractures associated with the use of benzodiazepines (anxiolytics, hypnotics and related drugs): a methodological approach to assess consistencies across databases from the PROTECT-EU project [O] . Requena, Gema, Huerta, Consuelo, Gardarsdottir, Helga, 2016

机译：与使用苯二氮卓类药物（抗焦虑药，催眠药和相关药物）相关的髋/股骨骨折：评估pROTECT-EU项目数据库一致性的方法学方法
8. The Influence of Yield Strength and Fracture Toughness on Fatigue Design Procedures for Structural Steels [R] . Crooker, T. W., Lange, E. A. 1970

机译：屈服强度和断裂韧度对结构钢疲劳设计程序的影响

Do case‐only designs yield consistent results across design and different databases? A case study of hip fractures and benzodiazepines

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