Magnitude of change with antidepressants and placebo in antidepressant clinical trials using structured taped and appraised rater interviews (SIGMA-RAPS) compared to trials using traditional semi-structured interviews

摘要

RationaleAlthough newer interview methods such as Structured Interview Guide for the Montgomery-Asberg Depression Rating Scale (SIGMA; MADRS) with audiotaping and Rater Applied Performance Scale (RAPS) appraisal have been introduced to improve reliability of ratings in antidepressant clinical trials, there is limited evidence that these methods actually improve trial outcome.