Four types of cannabimimetic indazole and indole derivatives ADB-BINACA AB-FUBICA ADB-FUBICA and AB-BICA identified as new psychoactive substances

摘要

We identified four cannabimimetic indazole and indole derivatives in new illegal psychoactive substances seized from a clandestine laboratory in China. These four derivatives included N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-benzyl-1H-indazole-3-carboxamide (ADB-BINACA, >1), N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indole-3-carboxamide (AB-FUBICA, >2), N-(1-amino-3,3-dimethyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indole-3-carboxamide (ADB-FUBICA, >3), and N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-benzyl-1H-indole-3-carboxamide (AB-BICA, >4). These compounds were identified by liquid chromatography–high-resolution mass spectrometry, gas chromatography–mass spectrometry, and nuclear magnetic resonance spectroscopy. No chemical or pharmacological data about compound >4 has appeared until now, making this the first report on this compound. Compounds >1, >2, and >3 have previously been reported to have a high affinity for cannabinoid CB1 and CB2 receptors, but this is the first report of their presence in illegal products.Electronic supplementary materialThe online version of this article (doi:10.1007/s11419-015-0297-2) contains supplementary material, which is available to authorized users.