Evaluation of in vitro antileishmanial efficacy of cyclosporin A and its non-immunosuppressive derivative dihydrocyclosporin A

摘要

CsA, DHCsA-d, or SSG treatment affects promastigotes multiplication and inhibition rates of promastigotes. Live promastigotes (LL quadrant) were assayed by flow cytometry at 24 h ( ) or 48 h ( ) after treatment with the individual drugs. Inhibition rates of promastigotes treated with different concentration of CsA and DHCsA-d at 24 h and 48 h. Inhibition rates of promastigotes treated with different concentration of SSG at 24 h and 48 h