Inhibition of RhoA/Rho-kinase pathway suppresses the expression of extracellular matrix induced by CTGF or TGF-β in ARPE-19

机译：RhoA / Rho激酶途径的抑制抑制CTGF或TGF-β诱导的ARPE-19中细胞外基质的表达

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摘要

AIMTo investigate the role of Rho-associated protein kinase (ROCK) inhibitor, Y27632, in mediating the production of extracellular matrix (ECM) components including fibronectin, matrix metallo-proteinase-2 (MMP-2) and type I collagen as induced by connective tissue growth factor (CTGF) or transforming growth factor-β (TGF-β) in a human retinal pigment epithelial cell line, ARPE-19.

机译：目的研究Rho相关蛋白激酶（ROCK）抑制剂Y27632在介导结缔组织诱导的细胞外基质（ECM）成分（包括纤连蛋白，基质金属蛋白酶-2（MMP-2）和I型胶原）的产生中的作用。人视网膜色素上皮细胞系ARPE-19中的组织生长因子（CTGF）或转化生长因子-β（TGF-β）。

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期刊名称 International Journal of Ophthalmology
作者
Jing Zhu; Duy Nguyen; Hong Ouyang; Xiao-Hui Zhang; Xiao-Ming Chen; Kang Zhang;
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作者单位

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年(卷),期 2013(6),1
年度 2013
页码 8–14
总页数 7
原文格式 PDF
正文语种
中图分类眼科学;
关键词
Rho-associated protein kinase inhibitor Connective tissue growth factor transforming growth factor-β proliferative vitreoretinopathy;

机译：Rho相关蛋白激酶抑制剂;结缔组织生长因子;转化生长因子-β;增殖性玻璃体视网膜病变;

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专利

1. Inhibition of RhoA/Rho-kinase pathway suppresses the expression of extracellular matrix induced by CTGF or TGF-β in ARPE-19 [J] . Jing Zhu, Duy Nguyen, Hong Ouyang, 国际眼科杂志：英文版 . 2013,第001期

机译：RhoA / Rho激酶途径的抑制抑制CTPE或TGF-β诱导的ARPE-19中细胞外基质的表达
2. Norcantharidin inhibits the expression of extracellular matrix and TGF-|[beta]|1 in HK-2 cells induced by high glucose independent of calcineurin signal pathway [J] . Ying Li, Qiong Chen, Fu-You Liu, Laboratory investigation . 2011,第12期

机译：去甲他汀抑制高糖诱导的HK-2细胞中钙调神经磷酸酶信号通路的细胞外基质和TGF- |β| 1的表达
3. Resveratrol suppresses TPA-induced matrix metalloproteinase-9 expression through the inhibition of MAPK pathways in oral cancer cells [J] . Lin Feng-Yan, Hsieh Yi-Hsien, Yang Shun-Fa, Journal of oral pathology and medicine: Official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology . 2015,第9期

机译：白藜芦醇通过抑制口腔癌细胞中的MAPK途径抑制TPA诱导的基质金属蛋白酶9表达
4. Role of mechanical-stress inducible protein Hcs24/CTGF/CCN2 in cartilage growth and regeneration: Mechanical stress induces expression of Hcs24/CTGF/CCN2 in a human chondrocytic cell line HCS-2/8, rabbit costal chondrocytes and meniscus tissue cells [C] . Takashi Nishida, Azusa Maeda, Satoshi Kubota, International Symposium on Mechanobiology of Cartilage and Chondrocyte . 2008

机译：机械应激诱导蛋白HCS24 / CTGF / CCN2在软骨生长和再生中的作用：机械应力在人软骨细胞系HCS-2/8中的HCS24 / CTGF / CCN2表达，兔肋骨软骨细胞和弯月面组织细胞
5. Connective tissue growth factor (CTGF) is a downstream mediator of TGF-β1 induced mesenchymal cell condensation [D] . Song, Jason J. 2008

机译：结缔组织生长因子（CTGF）是TGF-β1诱导的间充质细胞凝缩的下游介质
6. Simvastatin Increases Fibulin-2 Expression in Human Coronary Artery Smooth Muscle Cells via RhoA/Rho-Kinase Signaling Pathway Inhibition [O] . Noemí Serra, Roser Rosales, Lluís Masana, -1

机译：辛伐他汀通过RhoA / Rho激酶信号通路抑制增加人冠状动脉平滑肌细胞中Fibulin-2的表达
7. Betulinic acid prevents high glucose-induced expression of extracellular matrix protein in cardiac fibroblasts by inhibiting the TGF-β1/Smad signaling pathway [O] . Ling Jiang, Feng-Xia Chen, Shu-Ting Zang, 2017

机译：通过抑制TGF-β1/ SMAD信号通路，桦木酸可防止心肌成纤维细胞中细胞外基质蛋白的高葡萄糖诱导的表达

Inhibition of RhoA/Rho-kinase pathway suppresses the expression of extracellular matrix induced by CTGF or TGF-β in ARPE-19

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