Limited Weight Loss or Simply No Weight Gain following Lifestyle-Only Intervention Tends to Redistribute Body Fat to Decrease Lipid Concentrations and to Improve Parameters of Insulin Sensitivity in Obese Children

摘要

Objectives. To investigate whether lifestyle-only intervention in obese children who maintain or lose a modest amount of weight redistributes parameters of body composition and reverses metabolic abnormalities. Study Design. Clinical, anthropometric, and metabolic parameters were assessed in 111 overweight or obese children (CA of 11.3 ± 2.8 years; 63 females and 48 males), during 8 months of lifestyle intervention. Patients maintained or lost weight (1–5%) (group A; n: 72) or gained weight (group B). Results. Group A patients presented with a decrease in systolic blood pressure (SBP) and diastolic blood pressure (DBP) ( and , resp.), BMI (), z-score BMI (), waist circumference (), fat mass (), LDL-C (), Tg/HDL-C ratio (), fasting and postprandial insulin (), and HOMA (), while HDL-C () and QUICKI increased (). Conversely, group B patients had an increase in BMI (), waist circumference (), SBP (), and in QUICKI (), while fat mass ( alt="An external file that holds a picture, illustration, etc. Object name is 1687-9856-2011-241703-i17.gif" src="/pmc/articles/PMC3198742/bin/1687-9856-2011-241703-i17.gif" class="equation" />), fasting insulin ( alt="An external file that holds a picture, illustration, etc. Object name is 1687-9856-2011-241703-i18.gif" src="/pmc/articles/PMC3198742/bin/1687-9856-2011-241703-i18.gif" class="equation" />), and HOMA ( alt="An external file that holds a picture, illustration, etc. Object name is 1687-9856-2011-241703-i19.gif" src="/pmc/articles/PMC3198742/bin/1687-9856-2011-241703-i19.gif" class="equation" />) decreased. Lean mass, DBP, lipid concentrations, fasting and postprandial glucose, postprandial insulin, and ultrasensitive C-reactive protein (CRP) remained stable. Conclusions. Obese children who maintain or lose a modest amount of weight following lifestyle-only intervention tend to redistribute their body fat, decrease blood pressure and lipid levels, and to improve parameters of insulin sensitivity.