首页> 美国卫生研究院文献>International Journal of Stem Cells >Hepatogenic Differentiation Capacity of Human Wharton’s Jelly Mesenchymal Stem Cell in a Co-culturing System with Endothelial Cells in Matrigel/collagen Scaffold in the Presence of Fetal Liver Extract
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Hepatogenic Differentiation Capacity of Human Wharton’s Jelly Mesenchymal Stem Cell in a Co-culturing System with Endothelial Cells in Matrigel/collagen Scaffold in the Presence of Fetal Liver Extract

机译:胎肝提取物存在下基质胶/胶原支架中人沃顿氏胶质间充质干细胞与内皮细胞共培养系统的肝细胞分化能力

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摘要

BackgroundHuman Wharton’s jelly mesenchymal stem cells (HWJMSCs) isolated from medical waste product can be considered as an accessible source of cells in regenerative medicine. Stem cell-derived hepatocytes have poor function and need appropriate niche to reconstruct the liver structure. Therefore, we attempted to find a novel approach in differentiating HWJMSCs into functional hepatic cells using 3D culture conditions and liver extract that recapitulates vital stage in liver development.
机译:背景技术从医疗废物中分离出的沃顿商学院的果冻间充质干细胞(HWJMSC)可被视为再生医学中可及的细胞来源。干细胞来源的肝细胞功能差,需要适当的适当位置来重建肝脏结构。因此,我们试图找到一种新方法,利用3D培养条件和肝脏提取物将HWJMSCs分化为功能性肝细胞,从而概述了肝脏发育的关键阶段。

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