The aim of the current study was to formulate and optimize the formulation on the basis of in vitro performance of microsphere. A 32 full factorial design was employed to study the effect of independent variables, polymer-to-drug ratio (X 1) and stirring speed (X 2), on dependent variables, encapsulation efficiency, particle size, and time to 80% drug release. The best batch exhibited a high entrapment efficiency of 70% and mean particle size 290 μm. The drug release was also sustained for more than 12 hours. The study helped in finding the optimum formulation with excellent sustained drug release.
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