Three-Component Cascade Reaction of 11-Enediamines NN-Dimethylformamide Dimethyl Acetaland 13-Dicarbonyl Compounds: Selective Synthesis of Diverse 2-AminopyridineDerivatives

摘要

A novel approach has been developed for the synthesis of three kinds of highly functionalized 2-aminopyridine derivatives (APDs) through a three-component reaction of 1,1-enediamines (EDAMs) >1, N,N-dimethylformamide dimethyl acetal (DMF-DMA) >2, and 1,3-dicarbonyl compounds >3–>5 via a base-promoted cascade reaction, producing the desired products in good to excellent yields. This method represents a route to obtain a novel class of APDs in a concise, rapid, and practical manner. This approach is particularly attractive because of the following features: low cost, mild temperature, atom economy, high yields, and potential biological activity of the product.