Cutting fuel offers new clues in diabetic mystery

摘要

Competing theories have held opposite views on the role of flux through β-oxidation in causing insulin resistance. New transcriptomics, proteomics, and metabolomics data of skeletal muscle from mice in which lipid oxidation is limited by restricting entry of fat into mitochondria reveal extensive remodeling of metabolic pathways, consistent with an overall reduction in metabolic efficiency and improved metabolic health. These findings point to a potential new therapeutic approach for treating insulin resistance and type 2 diabetes.