Developing clinically practical transcranial direct current stimulation protocols to improve saccadic eye movement control

摘要

Recent research indicates that anodal transcranial direct current stimulation (tDCS) applied over the frontal eye field (FEF) can improve saccadic eye movement control in healthy young adults. The current research set out to determine whether similar results can be produced using a clinically practical protocol, whether tDCS applied over the dorsolateral prefrontal cortex (DLPFC) might also afford benefits, and whether benefits extend to older adults. Twenty young and 10 older adults completed two active (FEF and DLPFC) and one sham stimulation session. To aid clinical translation, the method of positioning the electrodes entailed simple measurements only. Saccadic performance following anodal tDCS applied over the FEF or DLPFC did not differ from the sham condition in either age group. Additionally, saccadic performance contralateral to the active electrodes showed no evidence of benefits over ipsilateral performance. These results call into question whether the protocol utilized can be applied effectively using only simple measurements to localize the relevant frontal subregion. Future efforts to develop a clinically practical tDCS protocol to improve saccadic eye movement control should include a sham control condition and consider adjusting the tDCS electrode montage and current strength to optimize the chances of conferring benefits in the population under study.