Are Adaptive Chemotherapy Schedules Robust? A Three-Strategy Stochastic Evolutionary Game Theory Model

摘要

We describe an evolutionary game theory mathematical model to investigate the robustness and accuracy of adaptive chemotherapy schedules in a stochastic environment in a tumor. The model assumes tumors are made up of a finite cell population of chemo-sensitive cells, and two populations of resistant cells, each resistant to one of two separate drugs that can be administered on different schedules. The goal of the adaptive schedules are to delay chemoresistance in the tumor by keeping the cell populations in competition with each other without any of the populations reaching fixation leading to treatment failure.