Bilateral atypical fractures of the femur: Ten years AFTER ten years of bisphosphonate therapy

摘要

Atypical femur fracture (AFF) is a clinically important complication of bisphosphonate (BP) use in the treatment of osteoporosis. The benefits of long-term BP therapy in preventing osteoporotic fractures have been shown to outweigh the risks of treatment. Discontinuation of BPs or “drug holidays” have been implemented as a strategy to reduce the risk of rare complications such as AFF.