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SCIDOT-15. DISRUPTING THE BLOOD-BRAIN BARRIER IN NEURO-ONCOLOGY: INNOVATIONS ACHIEVEMENTS AND LESSONS LEARNED FROM CLINICAL TRIALS

机译：Scidot-15。扰乱神经肿瘤学中的血脑屏障：从临床试验中吸取的创新成就和经验教训

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摘要

The blood-brain barrier (BBB) presents a formidable challenge for the development of effective therapeutics in neuro-oncology. Several strategies for the disruption of the BBB have been investigated in humans. An in-depth analysis of the concepts, design, and outcomes from these trials can provide insight into optimizing strategies for safe, selective, and efficacious BBB disruption for drug delivery.

机译：血脑屏障（BBB）对神经肿瘤学中有效治疗的发展具有强大挑战。已经在人类中调查了对BBB中断的几项策略。对这些试验的概念，设计和结果进行了深入的分析，可以深入了解优化安全，选择性和有效的BBB中断的药物递送的策略。

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期刊名称 Neuro-Oncology
作者
Justine Philtheos; Aram Abbasian; Brij Karmur; Alireza Mansouri;
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作者单位

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年(卷),期 2019(21),Suppl 6
年度 2019
页码 vi274
总页数 1
原文格式 PDF
正文语种
中图分类神经病学;肿瘤学;
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专利

1. Innovation in Clinical Trial Methodologies: Lessons Learned during the Corona Pandemic [J] . Norman M.Goldfarb Journal of Clinical Research Best Practices . 2021,第8期

机译：临床试验方法的创新：在科伦大流行期间的经验教训
2. Gadolinium deposition in the brain: Lessons learned from other metals known to cross the blood-brain barrier [J] . Prybylski John P., Maxwell Erin, Sanchez Carla Coste, Magnetic resonance imaging: An International journal of basic research and clinical applications . 2016,第10期

机译：d在大脑中的沉积：从已知穿过血脑屏障的其他金属中吸取的教训
3. Gadolinium deposition in the brain: Lessons learned from other metals known to cross the blood-brain barrier [J] . Prybylski John P., Maxwell Erin, Sanchez Carla Coste, Magnetic resonance imaging: An International journal of basic research and clinical applications . 2016,第10期

机译：大脑中的钆沉积：从其他金属中学到的经验教训，已知过血脑屏障
4. Lessons learned while implementing expert systems in the real world of clinical trials data analyses: The POSCH AI project [C] . Long, J.M., Slagle, Engineering of Computer-Based Medical Systems, 1988., Proceedings of the Symposium on the . 1988

机译：在临床试验数据分析的现实世界中实施专家系统时吸取的教训：POSCH AI项目
5. Preparedness for international AIDS vaccine trials: Lessons learned from a multi-site study of knowledge, attitudes, and willingness to participate (Thailand, China, India). [D] . Brown, Ami Shah. 2005

机译：国际艾滋病疫苗试验的准备：从对知识，态度和参与意愿的多站点研究中汲取的经验教训（泰国，中国，印度）。
6. Importance of dose intensity in neuro-oncology clinical trials: summary report of the Sixth Annual Meeting of the Blood-Brain Barrier Disruption Consortium. [O] . N. D. Doolittle, C. P. Anderson, W. A. Bleyer, 2001

机译：剂量强度在神经肿瘤临床试验中的重要性：血脑屏障破坏联盟第六届年会摘要报告。
7. Importance of dose intensity in neuro-oncology clinical trials: summary report of the Sixth Annual Meeting of the Blood-Brain Barrier Disruption Consortium. [O] . Doolittle, N. D., Anderson, C. P., Bleyer, W. A., 2001

机译：剂量强度在神经肿瘤临床试验中的重要性：血脑屏障破坏联盟第六届年会的总结报告。

SCIDOT-15. DISRUPTING THE BLOOD-BRAIN BARRIER IN NEURO-ONCOLOGY: INNOVATIONS ACHIEVEMENTS AND LESSONS LEARNED FROM CLINICAL TRIALS

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