Pathogenicity of severe fever with thrombocytopenia syndrome virus in mice regulated in type I interferon signaling: Severe fever with thrombocytopenia and type I interferon

摘要

Survival rate, weight loss, and body temperature of mice with different type I interferon signaling after SFTSV challenge. Three groups of mice, C57 BL/6 (WT), mice treated with blocking anti-type I interferon-α receptor antibody (IFNAR Ab), and IFNAR knockout (IFNAR−/−) mice, were intraperitoneally infected with four doses of SFTSV (KH1, 5 × 105 -5 × 102 FAID50). a Survival rates, b body weight (%), and body temperature (°C) were analyzed