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Navafenterol (AZD8871) in patients with mild asthma: a randomised placebo-controlled phase I study evaluating the safety tolerability pharmacokinetics and pharmacodynamics of single ascending doses of this novel inhaled long-acting dual-pharmacology bronchodilator

机译：Navafenterol（AZD8871）在轻度哮喘患者中：一种随机安慰剂对照期I研究评估本新型吸入剂量的单一升序剂量的安全性耐受性药代动力学和药效动物性能所述新型吸入剂量的长效二元药理学支气管扩张剂

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摘要

Patient disposition and flow

机译：患者处置和流动

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期刊名称 Respiratory Research
作者
Eulalia Jimenez; Carol Astbury; Muna Albayaty; Ulrika Wählby-Hamrén; Beatriz Seoane; Cristina Villarroel; Helena Pujol; Maria Jesus Bermejo; Ajay Aggarwal; Ioannis Psallidas;
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作者单位

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年(卷),期 2020(21),Suppl 1
年度 2020
页码 211
总页数 9
原文格式 PDF
正文语种
中图分类呼吸生理学;
关键词
Bronchodilator; Asthma; MABA; dual-pharmacology muscarinic receptor antagonist β;

机译：支气管扩张剂;哮喘;maba;双药理学毒蕈碱受体拮抗剂β;

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1. Navafenterol (AZD8871) in patients with mild asthma: a randomised placebo-controlled phase I study evaluating the safety, tolerability, pharmacokinetics, and pharmacodynamics of single ascending doses of this novel inhaled long-acting dual-pharmacology bronchodilator [J] . Eulalia Jimenez, Carol Astbury, Muna Albayaty, Respiratory Research . 2020,第S1期

机译：Navafenterol（AZD8871）在轻度哮喘患者中：一种随机安慰剂对照期I研究评估本新型吸入剂量的单一升序剂量的安全性，耐受性，药代动力学和药效动物性能，所述新型吸入剂量的长效二元药理学支气管扩张剂
2. Navafenterol (AZD8871) in healthy volunteers: safety, tolerability and pharmacokinetics of multiple ascending doses of this novel inhaled, long-acting, dual-pharmacology bronchodilator, in two phase I, randomised, single-blind, placebo-controlled studies [J] . Victor Balaguer, Muna Albayaty, Eulalia Jimenez, Respiratory Research . 2020,第S1期

机译：Navafenterol（AZD8871）在健康的志愿者中：这种新型吸入剂量的多个上升剂量的安全性，耐受性和药代动力学，两阶段I，随机，单盲，安慰剂对照研究中的多种升序，长效，双药理学支气管扩张剂
3. A Phase 1, Single-center, Double-blind, Placebo-controlled Study in Healthy Subjects to Assess the Safety, Tolerability, Clinical Effects, and Pharmacokinetics-Pharmacodynamics of Intravenous Cyclopropyl-methoxycarbonylmetomidate (ABP-700) after a Single Ascending Bolus Dose [J] . Struys Michel M. R. F., Valk Beatrijs I., Eleveld Douglas J., Anesthesiology . 2017,第1期

机译：健康受试者中的1阶段，单中心，双盲，安慰剂对照研究，以评估单个上升推注后静脉内环丙基 - 甲氧基甲氧基羰基金属酰胺酰胺酰胺（ABP-700）的安全性，耐受性，临床效果和药代动力学 - 药效学 - 药物动力学
4. Pharmacokinetics and Tolerability of Sublingual Fentanyl in Healthy Japanese and Caucasian Volunteers: Phase I, Open-Label Single-Dose Study [C] . U. Lorch, F. Farrell, J. Kilborn, International Pain Clinic Congress . 2008

机译：健康日本和白种人志愿者舌下芬太尼的药代动力学和耐受性：I期，开放标签单剂量研究
5. Navafenterol (AZD8871) in healthy volunteers: safety tolerability and pharmacokinetics of multiple ascending doses of this novel inhaled long-acting dual-pharmacology bronchodilator in two phase I randomised single-blind placebo-controlled studies [O] . Victor Balaguer, Muna Albayaty, Eulalia Jimenez, 2020

机译：Navafenterol（AZD8871）在健康的志愿者中：这种新型吸入剂量的多个上升剂量的安全性耐受性和药代动力学两阶段I随机单盲安慰剂对照研究
6. A phase I, placebo-controlled, randomized, double-blind, single ascending dose-ranging study to evaluate the safety and tolerability of a novel biophysical bronchodilator (S-1226) administered by nebulization in healthy volunteers [O] . 2016

机译：I期，安慰剂对照，随机，双盲，单次递增剂量范围研究，用于评估通过雾化在健康志愿者中施用的新型生物物理支气管扩张剂（S-1226）的安全性和耐受性

Navafenterol (AZD8871) in patients with mild asthma: a randomised placebo-controlled phase I study evaluating the safety tolerability pharmacokinetics and pharmacodynamics of single ascending doses of this novel inhaled long-acting dual-pharmacology bronchodilator

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