Impact of Prior Oncologic Treatment on Complications and Functional Outcomes in 1751 Head and Neck Free Flap Reconstruction Patients: An Institutional Analysis Using American College of Surgeons National Surgical Quality Improvement Program Methodology

摘要

PURPOSE: Patients with head and neck squamous cell carcinoma (HN-SCC) frequently present with locally advanced disease, and many develop locoregional recurrence. Treatment of locally advanced or recurrent HN-SCC often involves neoadjuvant chemotherapy and/or radiation. However, a knowledge gap exists regarding the interplay of toxicities from prior oncologic treatments on successful reconstruction. The aim of this study was to evaluate the effect of prior oncologic treatment, including chemotherapy, radiation, and/or surgery, on long-term outcomes and functional status after head and neck free flap reconstruction utilizing a prospectively maintained database modeled on the American College of Surgeons National Surgical Quality Improvement Program (NSQIP).