>Objective: To assess the safety and effectiveness of treating acne for eight weeks using a new blue light device at a dose of ˜2J/cm2/day (representing typical full-face treatment) or ˜29J/cm2/day (representing the typical dose after localized spot treatment of acne). >Design: Prospective, single-center, open-label study evaluating two levels of blue light in each subject. >Setting: Subjects were recruited from the local community for self-treatment at home. >Participants: Thirty-two subjects with mild or moderate facial acne vulgaris. >Measurements: Inflammatory lesion count; number, severity, and redness of flares; improvement in skin characteristics (overall appearance, clarity, radiance, tone, texture, and smoothness); tolerability; subject satisfaction. >Results: The blue light treatment was associated with significant reductions from baseline in inflammatory lesion count as early as Week 1 with ˜29J/cm2/day and Week 3 with ˜2J/cm2/day (P≤ 0.01). It was also associated with significant reductions in the number, severity, and redness of flares and with improvements in the skin’s appearance, clarity, radiance, tone, texture, and smoothness. Overall, 53 percent of subjects considered the treatment much gentler than traditional acne treatments and 61 percent were satisfied. Three adverse events were probably related to treatment—minimal transient skin dryness (2) and minimal transient hyperpigmentation (1). >Conclusion: The blue light treatment is effective and well tolerated, offering rapid, gentle, and convenient treatment of inflammatory acne. The blue light device offers a valuable alternative to antibiotics and potentially irritating topical treatments and can also be used adjunctively to complement other therapies.
展开▼
机译:>目的 strong>:评估使用新的蓝光设备(每天2J / cm 2 sup> /天)治疗痤疮八周的安全性和有效性(代表典型的面部治疗)或〜29J / cm 2 sup> /天(代表局部治疗痤疮后的典型剂量)。 >设计 strong>:一项前瞻性,单中心,开放标签的研究,评估每个受试者的两个蓝光水平。 >设置 strong>:受试者是从当地社区招募来在家接受自我治疗的。 >参与者 strong>:32名患有轻度或中度面部痤疮的受试者。 >测量结果 strong>:炎性病变计数;耀斑的数量,严重程度和发红;改善皮肤特征(整体外观,清晰度,光泽,色调,质地和光滑度);容忍度主题满意度。 >结果: strong>早在第1周,蓝光治疗与炎性病变计数的基线值显着减少相关,约为29J / cm 2 sup> /天,而第3周则约为2J / cm 2 sup> /天(P≤0.01)。它还与火炬的数量,严重程度和发红的显着减少以及皮肤的外观,清晰度,光泽,肤色,质地和光滑度的改善有关。总体而言,有53%的受试者认为该疗法比传统的痤疮疗法温和得多,并且61%的受试者满意。三个不良事件可能与治疗有关-短暂的短暂皮肤干燥(2)和最少的短暂色素沉着(1)。 >结论: strong>蓝光治疗有效且耐受良好,可快速,温和,方便地治疗炎性痤疮。蓝光设备是抗生素的宝贵替代品,可能会刺激局部治疗,还可以辅助使用以补充其他疗法。
展开▼