Corrigendum to A PLK1 kinase inhibitor enhances the chemosensitivity of cisplatin by inducing pyroptosis in oesophageal squamous cell carcinoma EBioMedicine 41 (2019) 244–255

摘要

BI2536 and DDP combination treatment led to caspase-3 activation, which induces pyroptosis by cleaving GSDME in ESCC cells. (a), The expression of several markers that reflect cell apoptosis was examined using Western blotting. Lysates from KYSE150 (left) and KYSE510 (right) cells were probed with antibodies after treatment with BI2536 (20 nM) or DDP (10 µM) or a combination of both at the same time for 24 h. (b), The expression of several markers that reflect the mitochondrial apoptotic pathways or autophagy was examined using Western blotting. Lysates from ESCC cells were probed with antibodies after the same treatment described in (a). (c), The expression of the indicated pyroptosis markers was examined using Western blotting. Lysates from ESCC cells were probed with antibodies after the same treatment described in (a).