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Development of a novel fully human anti-PCSK9 antibody with potent hypolipidemic activity by utilizing phage display-based strategy

机译：通过利用基于噬菌体显示的策略开发一种具有有效的低血散活性的新型全人抗PCSK9抗体

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摘要

Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates serum LDL cholesterol (LDL-C) levels by facilitating the degradation of the LDL receptor (LDLR) and is an attractive therapeutic target for hypercholesterolemia intervention. Herein, we generated a novel fully human antibody with favourable druggability by utilizing phage display-based strategy.

机译：ProProtein转化酶枯草杆菌蛋白酶/ kexin型9（PCSK9）通过促进LDL受体（LDLR）的降解来调节血清LDL胆固醇（LDL-C）水平，并且是一种具有高胆固醇血症干预的有吸引力的治疗靶标。在此，通过利用基于噬菌体显示的策略，我们通过利用噬菌体显示的策略产生了具有良好可用性的新型全人抗体。

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期刊名称 EBioMedicine
作者
Menglong Xu; Gaoxin Lei; Manman Chen; Ke Wang; Wenxiu Lv; Panpan Zhang; Tuo Hu; Jie Gao; Chenchen Lu; Ying Mei; Zhipan Xu; Zhengli Bai; Huajing Hu; Yiwei Jiang; Shuhua Tan;
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年(卷),期 2021(-1),-1
年度 2021
页码 -1
总页数 15
原文格式 PDF
正文语种
中图分类
关键词
PCSK9; Phage display; Human antibody; Affinity maturation; Hypercholesterolemia;

机译：PCSK9;噬菌体展示;人抗体;亲和力成熟;高胆固醇血症;

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专利

1. Phage Display-based Strategies for Cloning and Optimization of Monoclonal Antibodies Directed against Human Pathogens [J] . Laura Solforosi, Massimo Clementi, Matteo Castelli, International Journal of Molecular Sciences . 2012,第7期

机译：基于噬菌体展示的克隆和优化针对人类病原体的单克隆抗体的策略
2. Development of a Phage Display Panning Strategy Utilizing Crude Antigens: Isolation of MERS-CoV Nucleoprotein human antibodies [J] . Chia Chiu Lim, Patrick C. Y. Woo, Theam Soon Lim Scientific reports. . 2019,第1期

机译：利用粗抗原的噬菌体展示淘选策略的发展：MERS冠状病毒核蛋白人类抗体的分离。
3. Development of a Phage Display Panning Strategy Utilizing Crude Antigens: Isolation of MERS-CoV Nucleoprotein human antibodies [J] . Chia Chiu Lim, Patrick C. Y. Woo, Theam Soon Lim Scientific reports. . 2019,第1期

机译：利用粗抗原的噬菌体展示淘选策略的发展：MERS冠状病毒核蛋白人类抗体的分离。
4. Development and Characterization of a Human Anti-PCSK9 Antibody (BCD-096) [C] . Anastasia Ishutinova, A. Ulitin, S. Ageev, Protein Engineering Summit. . 2018

机译：人抗PCSK9抗体的开发和表征（BCD-096）
5. Streamlined development of fully human antibody fragments for immunopet imaging using phage display technology [D] . Li, Keyu 2014

机译：使用噬菌体展示技术简化了用于免疫宠物成像的完整人类抗体片段的开发
6. Phage Display-based Strategies for Cloning and Optimization of Monoclonal Antibodies Directed against Human Pathogens [O] . Nicola Clementi, Nicasio Mancini, Laura Solforosi, 2012

机译：基于噬菌体展示的克隆和优化针对人类病原体的单克隆抗体的策略
7. Phage Display-based Strategies for Cloning and Optimization of Monoclonal Antibodies Directed against Human Pathogens [O] . Roberto Burioni, Matteo Castelli, Massimo Clementi, 2012

机译：基于噬菌体展示的克隆和优化针对人类病原体的单克隆抗体的策略

Development of a novel fully human anti-PCSK9 antibody with potent hypolipidemic activity by utilizing phage display-based strategy

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