Oncosuppressive functions of PIDD1 in response to centrosome amplification

摘要

The cell cycle of cancer cells acquiring supernumerary centrosomes is arrested by a mechanism involving the recruitment of PIDD1 to the distal appendages of mature centrosomes via ANKRD26, followed by centrosome clustering, and PIDDosome signaling. This results in CASP2 activation, MDM2 degradation, and the initiation of a p53-dependent cascade arresting cell cycle progression.