M2-like macrophages exert hepatoprotection in acute-on-chronic liver failure through inhibiting necroptosis-S100A9-necroinflammation axis

摘要

a The hepatic damage assessed by serum ALT levels in mice challenged by D-GalN/LPS with or without necroptosis inhibitors. ***P < 0.001 compared with acutely injured mice. (n = 4–7) b The hepatic damage assessed by histopathology with H&E staining in mice challenged by D-GalN/LPS with or without necroptosis inhibitors. c The expression of M1 macrophage activation marker iNOS and M2 macrophage activation marker CD206 was detected by immunofluorescence in mice receiving D-GalN/LPS insult with or without necroptosis inhibitors.