Commentary on Interictal epileptogenic zone localization in patients with focal epilepsy using electric source imaging and directed functional connectivity from low‐density EEG

摘要

Resective epilepsy surgery is the most effective treatment option for patients with drug‐resistant focal epilepsy. Accurate localization of the epileptogenic zone (EZ) is necessary to achieve seizure freedom postoperatively. In challenging cases, this localization requires extensive testing, often including intracranial electroencephalography (iEEG) and complex neuroimaging. Multiple postprocessing tools aiming to “optimize the localization value” of such expensive and sophisticated work‐ups have exclusively focused on analyzing iEEG. On the upside, this undivided attention to iEEG has greatly advanced our understanding of epilepsy electrophysiology. On the downside, this lack of intellectual diversification is leaving all other sources of electrophysiological data, including the foundational scalp EEG, woefully under‐exploited. Herein lies the value of DrCoito's paper, selected for this year's Epilepsia Open Clinical Prize.