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Efficacy and Tolerability of a Fixed-Dose Combination of Rosuvastatin and Ezetimibe Compared with a Fixed-Dose Combination of Simvastatin and Ezetimibe in Brazilian Patients with Primary Hypercholesterolemia or Mixed Dyslipidemia: A Multicenter Randomized Trial

机译：罗苏伐他汀和欧塞蒂米贝的固定剂量组合的疗效和耐受性与司法素和欧洲血管血症患者的辛伐他汀和欧洲血管血症患者的固定剂量组合相比：多中心随机试验

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Background: The addition of ezetimibe to statin therapy has been reported to result in increased efficacy for reduction of LDL-C levels and achievement of lipid targets, compared with monotherapy.

机译：背景：据报道，与单药治疗相比，据报道，据报道，向他汀类药物添加到他汀类药物治疗的ezetimibe对他汀类药物治疗的疗效增加和脂质靶标的疗效增加。

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期刊名称 Current Therapeutic Research Clinical and Experimental
作者
Antonio Carlos Amedeo Vattimo; Francisco Antonio Helfestein Fonseca; Douglas Costa Morais; Larissa Fontes Generoso; Renata Herrera; Cristiane Moraes Barbosa; Maria Cristina de Oliveira Izar; Rita Antonelli Cardoso; Stevin Zung;
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年(卷),期 2020(93),-1
年度 2020
页码 -1
总页数 9
原文格式 PDF
正文语种
中图分类药学;医学史;
关键词
Hypercholesterolemia; Rosuvastatin plus ezetimibe; Single-pill combination; Sinvastatin plus ezetimibe;

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专利

1. A Phase III, Multicenter, Randomized, Double-blind, Active Comparator Clinical Trial to Compare the Efficacy and Safety of Combination Therapy With Ezetimibe and Rosuvastatin Versus Rosuvastatin Monotherapy in Patients With Hypercholesterolemia: I-ROSETTE (Ildong Rosuvastatin & Ezetimibe for Hypercholesterolemia) Randomized Controlled Trial [J] . Hong Soon Jun, Jeong Han Saem, Ahn Jeong Cheon, Clinical therapeutics . 2018,第2期

机译：III期，多中心，随机，双盲，活性比较试验，以比较与ezetimibe和罗萨凡汀单一的高胆固醇血症患者的疗效和安全性的疗效和安全性：I-ROSETTE（ILDONGROSUVASTATIMIBE用于高胆固醇血症）随机控制审判
2. Effect of fixed-dose combinations of ezetimibe plus rosuvastatin in patients with primary hypercholesterolemia: MRS-ROZE (Multicenter Randomized Study of ROsuvastatin and eZEtimibe) [J] . Kim Kyung-Jin, Kim Sang-Hyun, Yoon Young Won, Cardiovascular therapeutics . 2016,第5期

机译：依泽替米贝联合瑞舒伐他汀固定剂量联合治疗原发性高胆固醇血症的疗效：MRS-ROZE（瑞舒伐他汀和依泽替米贝的多中心随机研究）
3. Clinical Efficacy and Tolerability of Ezetimibe in Combination With Atorvastatin in Japanese Patients With Hypercholesterolemia-Ezetimibe Phase IV Randomized Controlled Trial in Patients With Hypercholesterolemia [J] . Tamio Teramoto, Teruo Sawada, Kazuya Iwamoto, Current therapeutic research, clinical and experimental. . 2012,第1a2期

机译：依泽替米贝联合阿托伐他汀在日本高胆固醇血症患者中的临床疗效和耐受性-依泽替米贝第四期高胆固醇血症患者的随机对照试验
4. Effect of fixed‐dose combinations of ezetimibe plus rosuvastatin in patients with primary hypercholesterolemia: MRS‐ROZE (Multicenter Randomized Study of ROsuvastatin and eZEtimibe) [O] . Kyung‐Jin Kim, Sang‐Hyun Kim, Young Won Yoon, -1

机译：依泽替米贝联合瑞舒伐他汀固定剂量联合治疗原发性高胆固醇血症的疗效：MRS-ROZE（瑞舒伐他汀和依泽替米贝的多中心随机研究）
5. A Phase III, Multicenter, Randomized, Double-blind, Active Comparator Clinical Trial to Compare the Efficacy and Safety of Combination Therapy With Ezetimibe and Rosuvastatin Versus Rosuvastatin Monotherapy in Patients With Hypercholesterolemia: I-ROSETTE (Ildong Rosuvastatin Ezetimibe for Hypercholesterolemia) Randomized Controlled Trial [O] . Soon Jun Hong, Han Saem Jeong, Jeong Cheon Ahn, 2018

机译：III期，多中心，随机，双盲，活性比较试验，以比较与ezetimibe和罗萨凡汀单一的高胆固醇血症患者的疗效和安全性的疗效和安全性：I-ROSETTE（ILDONGROSUVASTATIMIBE用于高胆固醇血症）随机控制审判

Efficacy and Tolerability of a Fixed-Dose Combination of Rosuvastatin and Ezetimibe Compared with a Fixed-Dose Combination of Simvastatin and Ezetimibe in Brazilian Patients with Primary Hypercholesterolemia or Mixed Dyslipidemia: A Multicenter Randomized Trial

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