Association between respiratory and herpes viruses on pulmonary exacerbations in cystic fibrosis patients

摘要

Respiratory viruses discovered in the 21st century and human herpes viruses (  = 13) were seldom (4/50) detected in our cystic fibrosis patients although exacerbation frequency (7.75 ± 2.9/a versus 4.45 ± 2.1/a;  = 0.03) and colonization with RR: 2.6; CI95: 1.8–3.7), (RR: 1.84; CI95: 1.4–2.4), and (RR: 1.5; CI95: 1.2–1.9) including MRSA (RR: 4.6; CI95: 1.3–16.6) were associated with virus positivity. Further studies should clarify whether this finding reflects non-specific colonization (human Bocavirus) or reactivation (Epstein-Barr virus) or rather an acceleration of lung tissue inflammation.