T33. EXPLORING THE ROLE OF WHITE MATTER INTEGRITY IN VERBAL MEMORY IN SCHIZOPHRENIA: DIFFERENT FINDINGS BETWEEN EPISODIC MEMORY AND WORKING MEMORY

摘要

Cognitive impairments are core symptoms in schizophrenia. Among them, memory deficits seem to be strongly related to several outcomes, such as psychosocial functioning and accelerated aging. However, the neurobiological mechanisms associated with this dysfunction are still unclear. One hypothesis would be related to white matter microstructural abnormalities, considering that neuronal connectivity underlies cognitive processing. Therefore, we aimed to study the relationship between white matter integrity in major tracts using diffusion tensor imaging (DTI) and episodic memory and working memory in individuals with schizophrenia (SZ) compared to healthy controls (HC).