Preventive chemotherapy and anthelmintic resistance of soil-transmitted helminths – Can we learn nothing from veterinary medicine?

摘要

Current parasite control programs in veterinary species have moved away from mass anthelmintic treatment approaches due to the emergence of significant anthelmintic resistance (AR), and the availability of few classes of anthelmintics. A number of parallels between livestock and human helminths exist that warn of the risk of AR in human soil-transmitted helminthiases, yet current public health interventions continue to prioritize mass treatment strategies, a known risk factor for AR. This review discusses the existing parallels between human and animal helminth biology and management, along with current public health recommendations and strategies for helminth control in humans. The effectiveness of current recommendations and alternative management strategies are considered.