Superoxide imbalance triggered by Val16Ala‐SOD2 polymorphism increases the risk of depression and self‐reported psychological stress in free‐living elderly people

摘要

Oxidative stress and chronic inflammatory states triggered by a single‐nucleotide polymorphism (SNP) in superoxide dismutase manganese‐dependent gene (Val16Ala‐SOD2) have been associated with the risk of developing several chronic, nontransmissible diseases. However, it is still not clear whether the VV‐SOD2 genotype that causes higher basal superoxide anion levels has any impact on the risk for depression and self‐reported psychological stress in elderly people.