Optimal process design space to ensure maximum viability and productivity in Penicillium chrysogenum pellets during fed-batch cultivations through morphological and physiological control

摘要

Experimental design of bioreactor cultivations (left). Factor ranges of bioreactor cultivations including nomenclature (right): additional cultivations exceeding the standard number of experiments along the P/V range (grey circles), centre-points (white circles), cultivations were setpoints could not be sustained due to external constraints (painted circles)