Lipopolysaccharide induces neuroglia activation and NF-κB activation in cerebral cortex of adult mice

摘要

Body weight ( ), reactive oxygen species (ROS) and lipid peroxidation (LPO) analyses ( ), and representative photomicrographs of hematoxylin and eosin staining ( - ) in the cerebral cortices of control and lipopolysaccharide (LPS)-treated animals. LPS induced a reduction of body weight ( ) and increases of DCF and MDA values ( ). LPS treatment induced severe histopathological changes including swelling and vacuolation of nerve cells ( and ). Arrows indicate normal pyramidal cells with well-characterized dendrites ( ). Open arrows indicate abnormal nerve cells that were swollen and vacuolated ( ). Arrowheads indicate shrunken neuroglial cells ( ). Magnified photos indicate square region. Scale bar = 100 μm ( and ), 200 μm ( and ). Data (  = 5) are shown as mean ± S.E.M.