PSIV-9 Roles of the nucleotide supplementation in nutrient digestibility stress hormone and reducing foot-and-mouth disease vaccinated stress reaction in growing pigs.

摘要

When the swine foot-and-mouth disease (FMD) vaccine injection, there will be stress reaction. Nucleotides are low-molecular-weight, intracellular compounds that are functional to numerous biochemical processes. They have important effects on the growth and development of rapid turnover cells, such as those in the immune system especially during stressful in animals. A 6 week trial was conducted to evaluate the effects of nucleotide supplementation in reducing FMD vaccine stress so as to improve their performance and immune system health in growing pigs. A total of 120 growing pigs [(Yorkshire x Landrace) x Duroc] with an average body weight of 25.76 ± 1.83 kg were used. Pigs were allocated to 1 of 3 treatments (8 pens per treatment; 3 barrows and 2 gilts per pen) based on body weight and sex. Dietary treatments consisted of: 1) CON: basal diet/FMD vaccine; 2) NUC1: CON + Nucleotide 0.5%/FMD vaccine; and 3) NUC2: CON + Nucleotide 1.0%/FMD vaccine. The statistical analysis was performed using randomized design by GLM procedure (SAS 9.2). Orthogonal polynomials were used to assess the linear and quadratic effects of increasing dietary NUC concentrations. In the current study, overall, the pigs had a higher G/F ratio in NUC diets, which was increased linearly (P = 0.025). The digestibility of dry matter (P = 0.02) and nitrogen (P = 0.03) showed significant increase (linear) in treatments, when compared to the controls. Meanwhile, after injection, there was a significant decrease (linear) in the level of cortisol in NUC treatments (P = 0.012) compared to controls in pigs. Also the epinephrine concentration were observed to be decreased linearly in NUC treatments (P = 0.011) compared with CON diet. In conclusion, thus nucleotide have positive effect on reducing vaccine stress as well as improving performance and immune system health in growing pigs.