Detection of anomalous high‐frequency events in human intracranial EEG

摘要

High‐frequency oscillations (HFOs) are a promising biomarker for the epileptogenic zone. However, no physiological definition of an HFO has been established, so detection relies on the empirical definition of an HFO derived from visual observation. This can bias estimates of HFO features such as amplitude and duration, thereby hindering their utility as biomarkers. Therefore, we set out to develop an algorithm that detects high‐frequency events in the intracranial EEG that are morphologically distinct from background without requiring assumptions about event amplitude or shape.