Metabolic Stability Assessment of Larotrectinib Using Liquid Chromatography Tandem Mass Spectrometry

机译：液相色谱串联质谱法评估拉罗替尼的代谢稳定性

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摘要

Larotrectinib (VITRAKVI) is an orally potent tropomyosin receptor kinase (Trk) inhibitor that acts by competitive inhibition of all corresponding receptor kinases. It demonstrated a marked response rate (75%) and robust anticancer activity in Trk fusion-positive patients. This response is independent of cancer type, age and gender.

机译：拉罗替尼（VITRAKVI）是一种口服有效的原肌球蛋白受体激酶（Trk）抑制剂，通过竞争性抑制所有相应的受体激酶发挥作用。它在Trk融合阳性患者中显示出显着的缓解率（75％）和强大的抗癌活性。该反应与癌症类型，年龄和性别无关。

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期刊名称 Drug Design Development and Therapy
作者
Mohamed W Attwa; Adnan A Kadi; Hany W Darwish;
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作者单位

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年(卷),期 2020(14),-1
年度 2020
页码 -1
总页数 9
原文格式 PDF
正文语种
中图分类药学;药物化学;
关键词
larotrectinib; human liver microsomes; metabolic stability evaluation; tandem mass spectrometry;

机译：拉罗替尼;人肝微粒体;代谢稳定性评价;串联质谱;

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1. 通过非靶向代谢组学和稳定同位素示踪技术分析索拉非尼耐药白血病细胞的代谢重编程和氧化还原适应 [J] . 游昕, 胡寓旻, 姜伟业, 癌症（英文版） . 2020,第007期
2. Metabolic Stability Assessment of Larotrectinib Using Liquid Chromatography Tandem Mass Spectrometry [J] . Mohamed W Attwa, Adnan A Kadi, Hany W Darwish Drug Design, Development and Therapy . 2020,第1期

机译：使用液相色谱串联质谱法的Larotrectinib的代谢稳定性评估
3. A simple liquid chromatography-tandem mass spectrometry method to accurately determine the novel third-generation EGFR-TKI naquotinib with its applicability to metabolic stability assessment [J] . Alrabiah Haitham, Kadi Adnan A., Attwa Mohamed W., RSC Advances . 2019,第9期

机译：一种简单的液相色谱 - 串联质谱法，可以精确地确定新的第三代EGFR-TKI Naquotinib，其适用于代谢稳定性评估
4. A simple liquid chromatography-tandem mass spectrometry method to accurately determine the novel third-generation EGFR-TKI naquotinib with its applicability to metabolic stability assessment [J] . Haitham Alrabiah, Adnan A. Kadi, Mohamed?W. Attwa, RSC Advances . 2019,第9期

机译：一种简单的液相色谱-串联质谱法可准确测定新型第三代EGFR-TKI纳替尼及其在代谢稳定性评估中的适用性
5. In-Vitro Metabolic Stability and Profiling of Ponatinib, Vandetanib and Masitinib using Liquid Chromatography Tandem Mass Spectrometry [C] . Adnan Kadi, Sawsan Amer, Hany Darwish, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：使用液相色谱串联质谱法的体外代谢稳定性和Ponatinib，Vandetanib和Masitinib的剖析
6. Detection of drugs of abuse within electronic cigarette liquids using gas chromatography-mass spectrometry and ultra fast liquid chromatography tandem mass spectrometry [D] . Walsh, Erin Elizabeth 2015

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7. Liquid chromatography tandem mass spectrometry method for the quantification of vandetanib in human plasma and rat liver microsomes matrices: metabolic stability investigation [O] . Sawsan M. Amer, Adnan A. Kadi, Hany W. Darwish, 2017

机译：液相色谱串联质谱法测定人血浆和大鼠肝微粒体基质中vandetanib的代谢稳定性
8. Validated liquid chromatography tandem mass spectrometry for simultaneous quantification of foretinib and lapatinib, and application to metabolic stability investigation [O] . Mohammed M. Alanazi, Hamad M. Alkahtani, Abdulrahman A. Almehizia, 2019

机译：验证液相色谱串联质谱法同时定量Foretinib和Lapatinib，以及代谢稳定性调查的应用

Metabolic Stability Assessment of Larotrectinib Using Liquid Chromatography Tandem Mass Spectrometry

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