Novel daily disposable therapeutic contact lenses based on chitosan andregenerated silk fibroin for the ophthalmic delivery of diclofenac sodium

摘要

The aim of this study was to investigate the possibility of chitosan and regenerated silkfibroin (CS/RSF) blended films as novel biomaterials for daily disposable therapeuticcontact lenses based ophthalmic drug delivery system. Diclofenac sodium (DS), ahydrophilic anti-inflammatory agent, was loaded into CS/RSF films by a soaking method. Thebest conditions of DS loading manifested the loading time of 2 h and pH 6.5 of drugsolution. The drug loading capacity and the drug release profile could be controlled byvarying the film RSF content. With increasing the film RSF content from 0 to 30%, theamount of loaded DS increased from 12 to 23 µg. Furthermore, the prolong drug releasedwithin therapeutic level was obtained with increasing the film RSF content. Consequently,a fast released characteristic within a therapeutic level up to 3 h was observed with the100CS/0RSF film. On the other hand, the 70CS/30RSF film demonstrated a significantprolonged drug release within therapeutic level up to 11 h. In conclusion, the CS/RSFfilms are promising as novel biomaterials for daily disposable therapeutic contactlenses-based ophthalmic delivery.