A simple method for inducing nonalcoholic steatohepatitis with fibrosis

摘要

Nonalcoholic fatty liver disease (NAFLD) is increasingly occurring in sedentary people, and may progress to NASH and hepatocellular carcinoma. It is essential to design affordable animal models for the study of various diseases, including fatty liver, which was the aim of the study. In this study, a high‐fat diet was devised that triggers NASH's animal model quickly and easily. High‐fat diet (HFD) was used both with intra‐mouth oral gavage and in combination with animal pellets.