Where do you want your drugs delivered?

摘要

Promoting bone repair and regeneration in bone fractures by local delivery of growth factors possessing osteoinductive activity has been extensively investigated with significant advancements. Methods such as a combination of biomaterial-based scaffold and local bone active molecule delivery has been used (Raina et al. ). Unfortunately, the local delivery approaches most often require surgery, and for some complex clinical fractures it is not possible to apply an invasive strategy because of access restrictions. Thus, to achieve efficient local concentrations and reduce systemic side effects, an ideal alternative method would be systemically administered targeted delivery of drugs due to ease of handling and precise spatiotemporal compatibility at fracture sites or sites of bone regeneration. However, the combination of delivery of osteopromotive molecules locally and systemically to enhance bone regeneration has been reported with limited success.