Self‐Supply of O2 and H2O2 by a Nanocatalytic Medicine to Enhance Combined Chemo/Chemodynamic Therapy

摘要

Combined chemo/chemodynamic therapy is a promising strategy to achieve an improved anticancer effect. However, the hypoxic microenvironment and limited amount of H O in most solid tumors severely restrict the efficacy of this treatment. Herein, the construction of a nanocatalytic medicine, CaO @DOX@ZIF‐67, via a bottom‐up approach is described. CaO @DOX@ZIF‐67 simultaneously supplies O and H O to achieve improved chemo/chemodynamic therapy. In the weakly acidic environment within tumors, CaO @DOX@ZIF‐67 is broken down to rapidly release the Fenton‐like catalyst Co and the chemotherapy drug doxorubicin (DOX). The unprotected CaO reacts with H O to generate both O and H O . The generated O relieves the hypoxia in the tumor and further improve the efficacy of DOX. Meanwhile, the generated H O reacts with Co ions to produce highly toxic •OH through a Fenton‐like reaction, resulting in improved chemodynamic therapy.