Ganoderma lucidum extract ameliorates MPTP-induced parkinsonism and protects dopaminergic neurons from oxidative stress via regulating mitochondrial function autophagy and apoptosis

摘要

GLE treatment promoted motor performance and protected against the loss of dopaminergic neuronal cells in MPTP-treated mice. Time required to cross the beam in the beam walking test in each group. Latency to fall in the rotarod test in each group. Quantification of TH-positive cells in the substantia nigra pars compact (SNpc) (left). IOD (integrated optical density) of TH-positive fibers in the striatum (right) among the different groups. Representative immunohistochemical images of TH labeling in the SNpc (upper) and striatum (lower), respectively. Data are expressed as the mean ± SEM;  = 15 in each group, *  P P #  ###