Karhunen-Loève Representation Distinguishes ST-T Wave Morphology Differences in Emergency Department Chest Pain Patients with Non-ST Elevation Myocardial Infarction Versus Non-Acute Coronary Syndrome

摘要

Patients presenting to the Emergency Department (ED) with chest pain are triaged to early reperfusion therapies based on their initial 12-lead electrocardiogram (ECG). The standard 12- lead ECG lacks sensitivity to detect acute myocardial infarction (AMI). Electrocardiographic diagnosis of non-ST elevation myocardial infarction (non-STEMI) is especially difficult and is delayed until cardiac biomarkers turn positive, indicating onset of myocardial necrosis.Study Aims:The purpose of this analysis was to extract global ST-T waveform features from chest pain patients, compare these features in patients with and without AMI, and then identify features that distinguish diagnostic categories.