Formal Alder-ene reaction of a bicyclo1.1.0butane in the synthesis of the tricyclic quaternary ammonium core of daphniglaucins

摘要

A tricyclic substructure of the tetracyclic nitrogen core of the daphniglaucins was formed by an oxidative activation of the allyl side chain of a bicyclo[1.1.0]butylmethylamine, a spontaneous intramolecular formal Alder-ene reaction, and a selective cyclization of a triol intermediate.