A single phenylalanine residue in the main intracellular loop ofα1 γ-aminobutyric acid type A and glycine receptors influences their sensitivity to propofol

摘要

BackgroundThe intravenous anaesthetic propofol acts as a positive allosteric modulator of glycine (GlyRs) and γ-aminobutyric acid type A (GABAARs) receptors. Although the role of transmembrane residues is recognized, little is known about the involvement of other regions in the modulatory effects of propofol. Therefore, we explored the influence of the large intracellular loop (LIL) in propofol sensitivity of both receptors.