Memantine an NMDA receptor antagonist differentially influences Go/No-Go performance and fMRI activity in individuals with and without a family history of alcoholism

摘要

RationaleIndividuals with a family history of alcoholism (family history positive [FHP]) show higher alcoholism rates and are more impulsive than those without such a family history (family history negative [FHN]), possibly due to altered N-methyl-D-aspartate (NMDA) receptor function.