Slow down to stay alive: HER4 protects against cellular stress and confers chemoresistance in neuroblastoma

摘要

BACKGROUNDNeuroblastoma (NBL) is a common pediatric solid tumor, and outcomes for advanced neuroblastoma remain poor despite extremely aggressive treatment. Chemotherapy resistance at relapse contributes heavily to treatment failure. The poor survival of high-risk patients urges investigation into novel treatment options and better understanding of resistance mechanisms. Based on our previous work and on data from publicly available studies, we hypothesized that Her4 contributes to resistance.