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Combined PI3K/mTOR and MEK Inhibition Provides Broad Antitumor Activity in Faithful Murine Cancer Models

机译：组合pI3K / mTOR和mEK抑制提供广泛的抗肿瘤活性在鼠忠实癌症模型

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PurposeAnticancer drug development is inefficient, but genetically engineered murine models (GEMM) and orthotopic, syngeneic transplants (OST) of cancer may offer advantages to in vitro and xenograft systems.

机译：目的抗癌药物开发效率低下，但是基因工程鼠模型（GEMM）和原位同基因同系移植（OST）可能为体外和异种移植系统提供优势。

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期刊名称 other
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Patrick J. Roberts; Jerry E. Usary; David B. Darr; Patrick M. Dillon; Adam D. Pfefferle; Martin C. Whittle; James S. Duncan; Soren M. Johnson; Austin J. Combest; Jian Jin; William C. Zamboni; Gary L. Johnson; Charles M. Perou; Norman E. Sharpless;
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年(卷),期 -1(18),19
年度 -1
页码 5290–5303
总页数 24
原文格式 PDF
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1. Combined PI3K/mTOR and MEK inhibition provides broad antitumor activity in faithful murine cancer models [J] . RobertsP.J., UsaryJ.E., DarrD.B., Clinical cancer research: an official journal of the American Association for Cancer Research . 2012,第19期

机译：结合的PI3K / mTOR和MEK抑制作用可在忠实的小鼠癌症模型中提供广泛的抗肿瘤活性
2. In vivo activity of combined PI3K/mTOR and MEK inhibition in a Kras(G12D);Pten deletion mouse model of ovarian cancer. [J] . Kinross KM, Brown DV, Kleinschmidt M, Molecular cancer therapeutics . 2011,第8期

机译：PI3K / mTOR和MEK联合抑制作用在卵巢癌Kras（G12D）; Pten缺失小鼠模型中的体内活性
3. PI3K/mTOR inhibitor PF-04691502 antitumor activity is enhanced with induction of wild-type TP53 in human xenograft and murine knockout models of head and neck cancer [J] . HerzogA., BianY., BroekR.V., Clinical cancer research: an official journal of the American Association for Cancer Research . 2013,第14期

机译：PI3K / mTOR抑制剂PF-04691502诱导人头颈癌异种移植和小鼠基因敲除模型中的野生型TP53可增强抗肿瘤活性
4. Gene Expression Profiling of LPS-Stimulated Murine Macrophages and Role of the NF-κB and PI3K/mTOR Signaling Pathways [C] . S. DOS SANTOS, A.-I. DELATTRE, F. DE LONGUEVILLE, Meeting on Cell Signaling World: Signal Transduction Pathways as Therapeutic Targets . 2007

机译：LPS刺激的小鼠巨噬细胞的基因表达谱以及NF-κB和PI3K / mTOR信号通路的作用
5. Targeting the MEK5, MEK1/2, and/or Pi3k Pathways Reverses Epithelial to Mesenchymal Transition and Enhances Chemotherapeutic Sensitivity in Breast and Brain Cancers with a Mesenchymal Phenotype [D] . Bhatt, Akshita B. 2021

机译：靶向MEK5，MEK1 / 2和/或PI3K途径将上皮细胞转型的上皮性反转，并通过间充质表型提高乳腺癌和脑癌中的化疗敏感性
6. Antitumor activity of selective MEK1/2 inhibitor AZD6244 in combination with PI3K/mTOR inhibitor BEZ235 in gefitinib-resistant NSCLC xenograft models [O] . Yiqing Qu, Xiuxiu Wu, Yunhong Yin, 2014

机译：选择性MEK1 / 2抑制剂AZD6244联合PI3K / mTOR抑制剂BEZ235在耐吉非替尼的NSCLC异种移植模型中的抗肿瘤活性
7. In Vivo Activity of Combined PI3K/mTOR and MEK Inhibition in a KrasG12D;Pten Deletion Mouse Model of Ovarian Cancer [O] . Kathryn M. Kinross, Daniel V. Brown, Margarete Kleinschmidt, 2011

机译：在KRASG12D中组合PI3K / MTOR和MEK抑制的体内活性; PTEN删除卵巢癌的小鼠模型

Combined PI3K/mTOR and MEK Inhibition Provides Broad Antitumor Activity in Faithful Murine Cancer Models

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