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Predictors of Outcome after Short-term Stabilization with Buprenorphine

机译:结果的预测因子与丁丙诺啡短期企稳后

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摘要

Using buprenorphine as a medication to treat opioid dependence is becoming more prevalent as illicit opiate use increases. Identifying the characteristics of opiate dependent individuals best suited to benefit from buprenorphine would improve guidelines for its administration. This study evaluates baseline and treatment participation variables for predicting positive response to short-term stabilization with buprenorphine. Data includes demographic, drug use, and other variables collected from participants undergoing stabilization over a 4-week period before being tapered off buprenorphine in a short-term detoxification process. Outcome variables include opioid use and retention. Logistic regression results indicate several characteristics associated with opioid use at the end of the stabilization period. These include being older, having no criminal history, and less opiate use. Criminal activity and opioid use in the last 30 days were significantly associated with shorter treatment stays. The benefits of identifying individual characteristics that may predict treatment response are discussed.
机译:随着非法鸦片使用量的增加,使用丁丙诺啡作为治疗阿片类药物依赖的药物变得越来越普遍。确定最适合从丁丙诺啡中受益的鸦片依赖个体的特征将改善其给药指南。这项研究评估了基线和治疗参与变量,以预测丁丙诺啡对短期稳定的积极反应。数据包括人口统计资料,药物使用情况和其他变量,这些变量是在短期解毒过程中从丁丙诺啡逐渐消失之前,经过4周稳定期的参与者收集的。结果变量包括阿片类药物的使用和保留。 Logistic回归结果表明在稳定期结束时与阿片类药物的使用相关的几个特征。其中包括年纪较大,没有犯罪记录和减少鸦片使用。最近30天内的犯罪活动和使用阿片类药物与住院时间短显着相关。讨论了确定可预测治疗反应的个体特征的好处。

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