A Diarylcyclopentendione Metabolite Obtained from a Preussia typharum Isolate Procured Using an Unconventional Cultivation Approach

摘要

An uncommon 2,5-diarylcyclopenteneone compound preussidone (>1) and a new biphenyl compound 1',5-dimethoxy-3,5'-dimethyl-2,3'-oxybiphenyl-1,2'-diol (>4), together with two known biphenyl compounds 5-methoxy-3,5'-dimethyl-2,3'-oxybiphenyl-1,1',2'-triol (>2) and cyperin (>3) were obtained from a Preussia typharum isolate that was procured using a panel of unconventional media formulations. The structures of the new compounds were established by NMR and mass spectrometry, while the absolute configuration of >1 was assigned by quantum chemical ECD and VCD calculations. The antimicrobial and DPPH radical scavenging activities of >1-4 were tested. Compounds >2 and >4 exhibited DPPH radical scavenging activities that were comparable to the positive control ascorbic acid.